3D MACROMOLECULE (GLUTAMINE)

Assalamualaikum w.b.t...

Hi,guys!!How are you today?? Have you read my previous post? I hope you put your comments there,because I really waiting to read your comments..

Today,I have new interesting topic for all of you.Do you know what is Glutamine??Here, I have some information about it...

Ok,let us learn about this one kind of Glutamine...

~Crystal Structure of the Murine Inhibitor of Carbonic Anhydrase~

Authors : Eckenroth, B.E., Mason, A.B., McDevitt, M.E., Lambert, L.A., Everse, S.J.

Citation: The structure and evolution of the murine inhibitor of carbonic anhydrase:A member of the transferrin superfamily.(2010) Protein Sci.

~Molecular Description~

Classification : Lyase Inhibitor
Structure Weigh : 302882.00
Molecule : Inhibitor of Carbonic Anhydrase
Compound : 1 Polymer
Type : polypeptide(L)
Length : 687
Chains : A, B, C, D
Fragment : Residues 20-700
Mutation : N489D , N664D
Molecule of the Month Features:
1) Ferritin and Transferrin
2) Serum Albumin

One More 3D Macromolecule's Picture Of Glutamine

The original signature of the transferrin (TF) family of proteins was the ability to bind ferric iron with high affinity in the cleft of each of two homologous lobes.However, in recent years new family members which do not bind iron have been discovered. One new member is the inhibitor of carbonic anhydrase (ICA), which as its name indicates, binds to and strongly inhibits certain isoforms of carbonic anhydrase. Recently mouse ICA has been expressed as a recombinant protein in a mammalian cell system. Here we describe the 2.4 A structure of mouse ICA from a pseudomerohedral twinned crystal. As predicted, the structure is bilobal, comprised of two alpha-beta domains per lobe typical of the other family members; as with all but insect TFs, the structure includes the unusual reverse gamma-turn in each lobe. The structure is consistent with the fact that introduction of two mutations in the N-lobe of mICA (W124R and S188Y) allowed it to bind iron with high affinity. Unexpectedly, both lobes of the mICA were found in the closed conformation usually associated with presence of iron in the cleft, and making the structure most similar to diferric pig TF. Two new ICA family members (guinea pig and horse) were identified from genomic sequences and used in evolutionary comparisons. Additionally, a comparison of selection pressure (dN/dS) on functional residues reveals some interesting insights into the evolution of the TF family including that the N-lobe of lactoferrin may be in the process of eliminating its iron binding function.


That's all I know about Glutamine for this time. If you have anything to share with me especially about Glutamine, don't forget to leave your comment!!

See you next time...Wslm..

~ JOURNEY OF LIFE ~

~ ALLAH IS EVERYTHING ~

Monday,19th July 2010...


IN THE NAME OF ALLAH, THE MOST GRACIOUS AND THE MOST MERCIFUL...All the praises be to Allah,The Creator and The Sustainer of the world.O My Lord ! Expand me my chest ,ease my task for me and remove the impediment from my speech...

ASSALAMUALAIKUM w.b.t

Alhamdulillah , we are very grateful to Allah because since now , we are still receiving "nikmat" Islam and Iman . To tighten and strengthen the bond of ukhuwah between us as muslims , we should always share , concerns , and remember towards each other . Allah s.w.t said in the Holy Quran in the chapter 49 , verse 10 , "Innamalmukminunalikhwah"-"All muslims are a single brotherhood"..Anyway , just to share....

`JOURNEY OF LIFE`

Life is a Journey

From once proximal end to other.


Life is a Journey

You are the traveler.

Life is a Journey

Your thoughts directs, your way in the journey.

Your virtue will be the fodder for your thoughts

This directs your way in the journey


Life is a Journey unpredictable journey where

You can't predict when you will start the

Journey and end the journey.


Life is a Journey and the time taken in the journey

Is the only time for you to reach your destiny


Life is a Journey Unavoidable journey.

The way, in which you want, you may travel.

And the way in which you will travel will show your destiny.

And so, try to travel in the way by which you can reach your destiny.



All of us , despite where we come from or our different backgrounds , are a single unity uphold by our aqidah and submission towards Allah swt..Thus,whatever path that you may have taken,firstly remember that anything you do is to receive the blessing from Allah swt.... We as muslims should always remember to Allah at any time and anyplace... From now , you should know which path is the best for you..Let us think about it...