3D MACROMOLECULE (GLUTAMINE)

Assalamualaikum w.b.t...

Hi,guys!!How are you today?? Have you read my previous post? I hope you put your comments there,because I really waiting to read your comments..

Today,I have new interesting topic for all of you.Do you know what is Glutamine??Here, I have some information about it...

Ok,let us learn about this one kind of Glutamine...

~Crystal Structure of the Murine Inhibitor of Carbonic Anhydrase~

Authors : Eckenroth, B.E., Mason, A.B., McDevitt, M.E., Lambert, L.A., Everse, S.J.

Citation: The structure and evolution of the murine inhibitor of carbonic anhydrase:A member of the transferrin superfamily.(2010) Protein Sci.

~Molecular Description~

Classification : Lyase Inhibitor
Structure Weigh : 302882.00
Molecule : Inhibitor of Carbonic Anhydrase
Compound : 1 Polymer
Type : polypeptide(L)
Length : 687
Chains : A, B, C, D
Fragment : Residues 20-700
Mutation : N489D , N664D
Molecule of the Month Features:
1) Ferritin and Transferrin
2) Serum Albumin

One More 3D Macromolecule's Picture Of Glutamine

The original signature of the transferrin (TF) family of proteins was the ability to bind ferric iron with high affinity in the cleft of each of two homologous lobes.However, in recent years new family members which do not bind iron have been discovered. One new member is the inhibitor of carbonic anhydrase (ICA), which as its name indicates, binds to and strongly inhibits certain isoforms of carbonic anhydrase. Recently mouse ICA has been expressed as a recombinant protein in a mammalian cell system. Here we describe the 2.4 A structure of mouse ICA from a pseudomerohedral twinned crystal. As predicted, the structure is bilobal, comprised of two alpha-beta domains per lobe typical of the other family members; as with all but insect TFs, the structure includes the unusual reverse gamma-turn in each lobe. The structure is consistent with the fact that introduction of two mutations in the N-lobe of mICA (W124R and S188Y) allowed it to bind iron with high affinity. Unexpectedly, both lobes of the mICA were found in the closed conformation usually associated with presence of iron in the cleft, and making the structure most similar to diferric pig TF. Two new ICA family members (guinea pig and horse) were identified from genomic sequences and used in evolutionary comparisons. Additionally, a comparison of selection pressure (dN/dS) on functional residues reveals some interesting insights into the evolution of the TF family including that the N-lobe of lactoferrin may be in the process of eliminating its iron binding function.


That's all I know about Glutamine for this time. If you have anything to share with me especially about Glutamine, don't forget to leave your comment!!

See you next time...Wslm..